On the bottle it says 2MG/ML
Okay, that's what we needed to know. And just so you understand...vets can have it compounded so that it's either a weaker or stronger concentration. So, to say that one vet dosed at 0.1ml and the other dosed it at 0.8ml, doesn't necessarily mean anything. It could have been a different concentration of the same drug from one vet to the other.
Based on James Carpenters 5th edition of Exotic Animal Formulary
, which is what I generally use as a guide, Benazepril has a range of effectiveness in rodents
0.05mg/kg to 0.1 mg/kg. It is recommended to give a dose once every 24 hours
, the dosage is a little higher:
0.25mg/kg to 0.5mg/kg. Again, recommended to be given once every 24 hours
Using the high-end rodent
recommendation, if Joy weighs roughly .9kg, the amount needed of the drug would be .09 milligrams (mg)
. 0.09 divided by the concentration of Benazepril in that bottle (2mg/ml) would be 0.045
milliliters. That dose is a very small amount -- not even 0.1ml.
Using the high-end amount for rabbits
of 0.5mg/kg, the amount needed of the drug would be 0.45 milligrams (mg)
. Divided by the concentration of Benazapril in the bottle (2mg/ml) equals a dose of 0.23 ml.
As you can see from this, with the concentration of Benazepril that you were given, you would be looking at giving somewhere between 0.05 ml and 0.2 ml. Your vet's recommendation of 0.1 ml would be within that range.
However...Pinta states that her vet uses a higher range:
From my vet: We usually used at least 1 mg/kg twice daily and occas went up to 2 mg/kg, if they weren't responding and if I recall correctly. I have always felt Fortekor to be very safe in GP's tho an overdose could cause low blood pressure and a very lethargic pig.
The dose would be 0.45
ml for Joy, based on that, twice a day. That would be substantially higher than what your vet has suggested. Pinta has a lot of experience with heart pigs (I do not), but as Pinta and Lynx both pointed out, nobody here can in good conscience say to you, "Yes, you should give Joy that much higher amount." Every animal is different. The fact that Joy seemed to crash on the amounts you were giving her (either from the upped Benazepril or upped Flusapex or both) would seem to point to it being too high or too frequent for her
. Just my opinion.
As a side note, I did notice in Plumb's Veterinary Drug Handbook
(8th edition) that Flusapex combined with Benazepril can
have an increased risk of hypotension (low blood pressure). One of the many symptoms of low blood pressure is loss of consciousness.