IVERMECTIN :: PRODUCTS
A Variety Of Ivermectin Products Can Be Used To Treat For Mites
Where to Find
SHEEP DRENCH contains 0.8 mg /ml meaning a 0.25ml dose will contain about 0.2 mg ivermectin. No dilution may be necessary, as a one cc (equivalent to one ml) syringe will relatively accurately measure oral doses in this range, adjusted for the weight of the animal.
Use sheep drench:
1% INJECTION (marketed for cattle) contains
10 mg/ml, meaning a 0.2 mg amount would be found in 2 hundredths of a ml. This amount would be difficult to accurately measure with commonly available syringes, but thoroughly mixing 9 ml propylene glycol with 1 ml of this form of ivermectin, results in a concentration of 1 mg/ml, a solution that allows for more accurate oral dosing. For example, a guinea pig weighing a kilo and requiring a 0.2mg dose of ivermectin, could be treated with 0.2 ml of the described solution (1 part injectable to 9 parts other). can be diluted and used orally
Use 1% injectable ivermectin:
Orally (usually diluted)
By injection (undiluted)
HORSE PASTE (Zimecterin, Equimectrin -- generally available as a paste) commonly comes in a tube of 0.21 oz. (6.08 g) that will treat up to 1250 pounds of horse. The tube is designed to dispense treatment for different weights of horse. Since horses appear to be dosed at the same rate as guinea pigs, one tube could treat 1250 pounds of cavy. This 1.87% tube contains 113.7 mg ivermectin which requires dilution with an inert substance (usually propylene glycol) to achieve proper doses. Using the 250 pound mark (22.74 mg ivermectin -- 20% of the original 113.7 mg) and adding 22.0 cc of propylene glycol yields a maximum dose of 1.00 mg ivermectin per ml. The volume of the paste is unknown (it is listed in ounces by weight, not in fluid ounces by volume) and the addition of the paste to propylene glycol reduces the amount of active ingredient per ml. However, because of the apparently small volume, it is still possible to estimate doses using this product safely -- the estimates will simply err on the high side (so your cavy will get slightly less than the recommended dose). This product is very concentrated and must be mixed thoroughly to avoid overdosing.
Use horse paste:
WHERE TO PURCHASE Ivermectin is available over-the-counter. Many areas of the country have farm supply stores like Southern States Farm Cooperative where it can be easily purchased. A search on the internet under "ivermectin" and "veterinary supply" will turn up other sources for these products. Valley Vet is a popular online supplier of low-cost generic ivermectin.
Remember that you are advised to SEE A VET to ensure your guinea pig is properly treated for mites.
PROPYLENE GLYCOL. Some people question the safety of propylene glycol. For sheep, the most toxic side effects appear to be the result of the carrier (propylene glycol) and not the orally administered ivermectin. (See "Toxic Syndrome": (FDA - NADA 131-392) -- "In conclusion. the adverse effects observed in the sheep given ivermectin formulated in propylene glyco1 seemed to be more attributable to the vehicle than to ivermectin."
Mandigers et al. (1993) reported subdermal necrosis at the injection site in the young and skin inflammation in older animals, suggesting propylene glycol was the cause. My large animal vet friend prefers to avoid using propylene glycol for dilutions and instead uses vegetable oil, mixing it for immediate use. She does not know how shelf life is affected if the dilution is stored. It is also possible to dilute some forms of ivermectin with water for immediate use.